Work

Adolescent predatory stress increases peripheral TNFα response to LPS regardless of sex

Year: 2021

Type: preprint

Abstract: Chronic adolescent stress has been shown to cause increased adverse effects in response to an immune stressor later in life including the development of anxiety and PTSD. Following stress, the production of inflammatory cytokines including IL-1β and TNFα is expected to increase in response to an immune challenge such as LPS. Male and female mice underwent fifteen consecutive days of predatory stress. Chronic adolescent stress was shown to increase both anxiety-like behavior (F (1, 28) = 19.82, p = 0.0001) and TNFα levels within the periphery (F (1, 19) = 4.748, p = 0.0421).

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2021.01.25.427666

Authors: Samya K. Dyer, Susie Turkson, Gladys A. Shaw, Gretchen N. Neigh

Institution: Virginia Commonwealth University

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Virginia Commonwealth University, National Institute of Nursing Research