Work

Genetic diversity of Mycobacterium bovis and its zoonotic potential in Ethiopia: A scoping review

Year: 2020

Type: article

Abstract: Background: In developing countries like Ethiopia bovine tuberculosis (TB) primarily caused by Mycobacterium bovis (M. bovis) is still the cause of significant public health and economic burden due to lack of control policies and infrastructure limitations. Understanding the types of M. bovis strains circulating in a country and exploring its zoonotic potential has a significant contribution in the effort to design control program. The main aim of this study was to review and compile the results of studies conducted on strains of M. bovis from animal and human in Ethiopia. Methods & Materials: A systematic search and review of articles published on M. bovis strains in Ethiopia were made. PubMed and Google Scholar databases were considered for the search while the keywords used were “Mycobacteria,” “Mycobacterium bovis,” “Bovine Tuberculosis” and “Ethiopia.” Results: Fourteen studies were considered in this review and a total of 44,993 cattle; 1744 Goats; 1600 Camels and 2619 Human were involved. Geographically, the genotype of M. bovis was reported from Oromia (50%), Amhara (23%) Addis Ababa (19%), South Nation and Nationalities People (SNNP) (7%) and Ethiopian Somali (1%) regions of Ethiopia. A total of 31 distinct strains of M. bovis (N = 211) were obtained; the most dominant strains were SB0133 (N = 62, 29.4%), SB1176 (N = 61, 28.9%), and followed by SB0134 and SB1476 each (N = 18, 8.5%). Regarding the clustering rate, 42.0% of the similar strains of M. bovis were found to be reported more than ones. On the other hand, only (N = 4, 2.0% of the strains reported were found to be new strains that were not registered on M. bovis database. On the other hand, 6 distinct strains of M. bovis (N = 11, 5.2%) were reported from human subjects namely; SB0665 (N = 4), SB0303 (N = 2), SB0982 (N = 2), SB0133 (N = 1), SB1176 (N = 1), and 1 new strain. Conclusion: The result showed that the genetic diversity of M. bovis strains reported from Ethiopia are less diversified and highly clustered. And also the result underlines that there is ongoing active transmission of M. bovis between human and animals in Ethiopia because a significant number of strains were reported from human and animals.

Source: International Journal of Infectious Diseases

DOI: 10.1016/j.ijid.2020.09.1397

Authors: B.T. Eticha, G. Ameni

Institution: Addis Ababa University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,750