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Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Year: 2020
Type: article
Study design: Observational Study
Abstract: In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
Authors: McGlinchey, Aidan, Sinioja, Tim, Lamichhane, Santosh, Sen, Partho, Bodin, Johanna Eva, Siljander, Heli, Dickens, Alex M., Geng, Dawei, Carlsson, Cecilia, Duberg, Daniel, Ilonen, Jorma, Virtanen, Suvi M., Dirven, Hubert, Berntsen, Hanne Friis, Zimmer, Karin Elisabeth, Nygaard, Unni Cecilie, Orešič, Matej, Knip, Mikael, Hyötyläinen, Tuulia
Institutions: Örebro University, Åbo Akademi University, University of Turku, Norwegian Institute of Public Health, Turku University Hospital, National Institute of Occupational Health, Norwegian University of Life Sciences, Tampere University Hospital, University of Helsinki, Helsinki University Hospital, Helsinki Children's Hospital
Language: English
Open Access status: green
OpenAlex ID: W3121474175
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