Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets
Year: 2021
Type: article
Abstract: Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant proteins to adsorb to nanocarrier surfaces, a process that is considered benign or beneficial by minimizing opsonization or inflammation. Here, we demonstrate the surface chemistry of a model nanocarrier can be engineered to stabilize or denature the three-dimensional conformation of adsorbed albumin, which respectively promotes evasion or non-specific clearance in vivo. Interestingly, certain common chemistries that have long been considered to convey stealth properties denature albumin to promote nanocarrier recognition by macrophage class A1 scavenger receptors, providing a means for their eventual removal from systemic circulation. We establish that the surface chemistry of nanocarriers can be specified to modulate adsorbed albumin structure and thereby tune clearance by macrophage scavenger receptors.
Source: Nature Communications
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $5,560
Funders: National Science Foundation, U.S. Department of Energy, U.S. Department of Health and Human Services, Dow Chemical Company, DuPont, Northwestern University, National Institutes of Health, Office of Science, University of California, Los Angeles, Robert H. Lurie Comprehensive Cancer Center, Materials Research Science and Engineering Center, Harvard University, International Institute for Nanotechnology, Northwestern University, National Heart, Lung, and Blood Institute, NIH Office of the Director, National Cancer Institute, National Institute of General Medical Sciences, Division of Materials Research, Division of Electrical, Communications and Cyber Systems, California NanoSystems Institute, Argonne National Laboratory
Awards: G1004323642, G102163711, G107546177, G1164661550, G1169090945, G1194159565, G1218932987, G1276186940, G1284175734, G1313983767, G1329306526, G1382277591, G1497003984, G1505794299, G156040952, G1664757510, G1697802790, G2101401529, G2137585358, G2287611682, G23745306, G262962599, CAREER: Rational design of a biomimetic nanomaterial library to probe mechanisms behind virus-induced immunopathology, G2873586948, G2887060908, G2980159964, G3075337988, G3152346458, Development of combination immunotherapies for atherosclerotic inflammation, G317886719, G3247831757, G336680401, G340565428, G3454132534, G3589692066, G3954585026, G4001230836, G4159268500, G4227059234, G4285583887, G4289625387, G4372147948, MRI: Development of a Cryogenic Sample-Preparation Instrument (NU CRYOCLUSTER), G4433393426, MRSEC: Center for Multifunctional Materials, G4912152698, G498139845, G5106849484, G513797252, G5162417229, G5218300437, G5607048534, NNCI: Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource, G6038498354, G6544658276, G6671297155, G6848031779, G6918803902, Chemistry of Life Processes Predoctoral Training Program, G7304483037, G7368700025, G7570481651, G801469781, G8073314406, G8230932042, G875283887, G9000046704, G9000150115, G9000243582, G9000243610, The Robert H. Lurie Comprehensive Cancer Center, G969889393, G991892393, G993121649, G993149817
OpenAlex ID: W3121844935