Work

A new lease on life for an HIV-neutralizing antibody class and vaccine target

Year: 2021

Type: editorial

Abstract: We utilized various mouse models of IBD to demonstrate that TL1A expression on the surface of DCs is increased in inflamed intestines. Moreover, Tl1a−/− naive CD4+ T cells exhibited impaired ability for Th1 or Th17 differentiation ex vivo, and ...The binding of tumor necrosis factor–like cytokine 1A (TL1A) to death receptor 3 (DR3) plays an important role in the interaction between dendritic cells (DCs) and T cells and contributes to intestinal inflammation development. However, the mechanism by ...

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2026390118

Author: Dennis R. Burton

Institutions: Scripps Research Institute, International AIDS Vaccine Initiative, Ragon Institute of MGH, MIT and Harvard

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3122195536

Cites: 21

Cited by: 5

Related to: 10