Work

Efflux pumps potential drug targets to circumvent drug Resistance – Multi drug efflux pumps of Helicobacter pylori

Year: 2021

Type: article

Abstract: Helicobacter pylori (H. pylori) being grouped as Group1 Carcinogen by World Health Organisation (WHO) is arising as multidrug resistant (MDR), necessitating efficacy in current therapeutic approach. Efflux pump plays the major role in development of MDR strains in H.pylori. Ubiquitous nature and substrate specificity is engendering efflux pumps as potent drug targets. Structural analogy of transport family members would abide to the successful development of EPIs for abolishment of MDR strains. This review elaborates the drug resitance in H. pylori and the associated multidrug efflux pumps further review have a summarised list of transport members in each efflux family.

Source: Materials Today Proceedings

DOI: 10.1016/j.matpr.2020.11.955

Authors: Divya S. Raj, Dinesh Kumar Kesavan, Natarajan Muthusamy, S. Umamaheswari

Institutions: Manonmaniam Sundaranar University, Jiangsu University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $150