Year: 2021
Type: review
Abstract: Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue macrophages in the body. Within the liver sinusoids Kupffer cells perform functions common across many tissue macrophages including response to tissue damage and antigen presentation. They also engage in specialized activities including iron scavenging and the uptake of opsonized particles from the portal blood. Here, we review recent studies of the epigenetic pathways that establish Kupffer cell identity and function. We describe a model by which liver-environment specific signals induce lineage determining transcription factors necessary for differentiation of Kupffer cells from bone-marrow derived monocytes. We conclude by discussing how these lineage determining transcription factors (LDTFs) drive Kupffer cell behavior during both homeostasis and disease, with particular focus on the relevance of Kupffer cell LDTF pathways in the setting of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
Source: Frontiers in Immunology
Institutions: University of California San Diego, Nippon Medical School
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: A Cardiovascular-NASH disease nexus: Common Mechanisms and Treatments?, LEAN (Leducq Epigenetics of Atherosclerosis Network) Defining and targeting epigenetic pathways in monocytes and macrophages that contribute to cardiovascular disease., G4031813085, G4105965144, G4617511884, G5409294738, G6565996450, Interleukin 18 and Atherosclerosis during Stress, Interrogating Liver Macrophage LXR Signaling in Health and Non-Alcoholic Fatty Liver Disease, Role of Immune Mechanisms in Athersclerosis and Inflammation, Training Grant in Gastroenterology, Medical Scientist Training Program, G9000035401, G9000140433, Contemporary Approaches to Cancer Cell Signaling and Communication, Diabetes Research Center (DRC), Experimental Endocrinology and Metabolism, Transcriptional co-regulators and macrophage gene expression
OpenAlex ID: W3122351617