Year: 2021
Type: review
Abstract: The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism.
Source: Endocrine
Institutions: University of Milan, IRCCS Istituto Auxologico Italiano, Ghent University Hospital, Ghent University, Great Ormond Street Hospital, University College London, Queen Mary University of London, William Harvey Research Institute, Aarhus University Hospital, University of Copenhagen, Rigshospitalet
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,860
Funder: Università degli Studi di Milano
OpenAlex ID: W3122919786