Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Observational studies have reported either null or weak protective associations for coffee consumption and risk of breast cancer. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between coffee consumption and breast cancer risk using 33 single-nucleotide polymorphisms (SNPs) associated with coffee consumption from a genome-wide association (GWA) study on 212,119 female UK Biobank participants of White British ancestry. Risk estimates for breast cancer were retrieved from publicly available GWA summary statistics from the Breast Cancer Association Consortium (BCAC) on 122,977 cases (of which 69,501 were estrogen receptor (ER)-positive, 21,468 ER-negative) and 105,974 controls of European ancestry. Random-effects inverse variance weighted (IVW) MR analyses were performed along with several sensitivity analyses to assess the impact of potential MR assumption violations. RESULTS: One cup per day increase in genetically predicted coffee consumption in women was not associated with risk of total (IVW random-effects; odds ratio (OR): 0.91, 95% confidence intervals (CI): 0.80-1.02, P: 0.12, P for instrument heterogeneity: 7.17e-13), ER-positive (OR = 0.90, 95% CI: 0.79-1.02, P: 0.09) and ER-negative breast cancer (OR: 0.88, 95% CI: 0.75-1.03, P: 0.12). Null associations were also found in the sensitivity analyses using MR-Egger (total breast cancer; OR: 1.00, 95% CI: 0.80-1.25), weighted median (OR: 0.97, 95% CI: 0.89-1.05) and weighted mode (OR: 1.00, CI: 0.93-1.07). CONCLUSIONS: The results of this large MR study do not support an association of genetically predicted coffee consumption on breast cancer risk, but we cannot rule out existence of a weak association.
Source: PLoS ONE
Institutions: Imperial College London, Centre international de recherche sur le cancer, University College London, Oslo University Hospital, Oslo Nye Høyskole, QIMR Berghofer Medical Research Institute, University of Bristol, MRC Integrative Epidemiology Unit, University Hospitals Bristol NHS Foundation Trust, National Institute for Health and Care Research, NIHR Bristol Biomedical Research Centre, University of Ioannina
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,749
Funders: World Health Organization, Centre International de Recherche sur le Cancer, Genome Canada, University Hospitals Bristol NHS Foundation Trust, World Cancer Research Fund International, Government of Canada, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, University of Bristol, National Institutes of Health, Canadian Institutes of Health Research, Medical Research Council, World Cancer Research Fund, National Cancer Institute
Awards: G104449235, G1131969086, G1389895161, G149876332, G1614944260, G173885373, G1955001954, G1987169411, G2293058991, G235045266, Discovery, Biology and Risk of Inherited Variants in Breast Cancer, G2642749895, G2809956348, G301055538, G3217467674, G3288244108, G3344456887, G3385934250, G3718558835, G3807225764, G3830541857, G4339904293, G476489484, G4807506537, G5001017760, G5181373253, UK Biobank (core renewal), G5747748742, G6119919417, G6370857267, G6423108142, G6682065591, Mendelian randomization to hypothesis-free causal inference, G6971553973, G738105237, G76752795, G7698318594, G829717837, G8668082143, Weight change and the onset and progression of cardiovascular diseases in large-scale electronic health records, G9000200580
OpenAlex ID: W3122929465