Work

Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood

Year: 2021

Type: article

Abstract: Export of vasodilator ATP from red blood cells requires pannexin 1. Blood plasma ATP elevations in response to hypoxia in mice require pannexin 1. Hemodynamic responses to hypoxia are accompanied by increased plasma ATP in mice in vivo and require pannexin 1.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00651.2020

Authors: Brett S. Kirby, Matthew A. Sparks, Eduardo R. Lazarowski, Denise A. Lopez Domowicz, Hongmei Zhu, Timothy J. McMahon

Institutions: Duke Medical Center, Durham VA Medical Center, University of North Carolina at Chapel Hill, Duke University

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences