Work

Study Protocol: Seven vs. 14 days treatment for afebrile men with urinary tract infection

Year: 2021

Type: article

Abstract: The optimal treatment duration for men with urinary tract infection (UTI) is poorly defined. Observational data suggests that shorter-duration therapy may perform as well as longer-duration therapy, but trial data are lacking. We present the protocol and methods for a Department of Veterans Affairs-funded trial of seven vs. 14 days of antimicrobial therapy for afebrile men with UTI, with the primary outcome of symptom resolution 14 days after completing active antimicrobial treatment. An optional sub-study will investigate the effect of treatment duration on the intestinal carriage of antimicrobial-resistant microorganisms. Subjects are enrolled after their UTI is diagnosed and treatment initiated, using a combination of in-person and mail enrollment to maximize participation and minimize resource utilization. This trial will provide high-quality evidence to guide the management of a common infectious disease and potentially limit unnecessary antimicrobial use.

Source: Contemporary Clinical Trials Communications

DOI: 10.1016/j.conctc.2021.100714

Authors: Carla Amundson, James Johnson, Barbara Trautner, Dimitri Drekonja

Institutions: Minneapolis VA Health Care System, University of Minnesota, Michael E. DeBakey VA Medical Center, Baylor College of Medicine

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,890