Work

The Role of GSH in Intracellular Iron Trafficking

Year: 2021

Type: review

Abstract: Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms22031278

Authors: Robert Hider, Mayra Vera Aviles, Yu-Lin Chen, Gladys Oluyemisi Latunde-Dada

Institution: King's College London

Language: English

Topic: Biochemical effects in animals

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $2,160

OpenAlex ID: W3123090367

FWCI: 1.058

Cites: 75

Cited by: 52

Related to: 10