Work

DNA methylation perturbations may link altered development and aging in the lung

Year: 2021

Type: article

Study design: Observational Study

Abstract: ) and implicated in developmental processes including embryonic organ morphogenesis, neurogenesis and growth delay. Hypo-methylated CpGs (2%) were enriched in oxido-reductase activity and VEGFA-VEGFR2 Signaling. Twenty-one age-by-sex and eleven age-by-pack-years interactions were statistically significant (FDR<0.05) in adult-lung tissue. DNA methylation in transcription factors during development in fetal lung recapitulates in adult-lung tissue with aging. These findings reveal molecular mechanisms and pathways that may link disrupted development in early-life and age-associated lung diseases.

Source: Aging

DOI: 10.18632/aging.202544

Authors: Priyadarshini Kachroo, Jarrett D. Morrow, Carrie A. Vyhlidal, Roger Gaedigk, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, Dawn L. DeMeo

Institutions: Brigham and Women's Hospital, Children's Mercy Hospital

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: CIGARETTE SMOKE IMPACTS FETAL LUNG DNA METHYLATION AND GENE EXPRESSION, Systems Biology of Airway Disease, INTRAUTERINE SMOKE EXPOSURE AND ASTHMA: GENOMIC ORIGINS, Integrative omics pipeline to identify novel COPD genes and pathways, Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers

OpenAlex ID: W3123422291

FWCI: 0.627

Cites: 70

Cited by: 11

Related to: 10