The Canonical Long-Chain Fatty Acid Sensing Machinery Processes Arachidonic Acid To Inhibit Virulence in Enterohemorrhagic Escherichia coli
Year: 2021
Type: article
Abstract: (EHEC). We show that long-chain fatty acids including arachidonic acid act as signaling molecules that directly suppress a key pathogenicity island in EHEC following recognition by the fatty acyl-CoA-responsive transcription factor FadR. Thus, in addition to its established effects on host immunity and its bactericidal activities against other pathogens, we demonstrate that arachidonic acid also acts as a signaling molecule that inhibits virulence in an enteric pathogen.
Source: mBio
Authors: Melissa Ellermann, Angel G. Jimenez, Reed Pifer, Nestor Ruiz, Vanessa Sperandio
Institution: The University of Texas Southwestern Medical Center
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: Quorum sensing regulation of EHEC virulence genes, Regulation of Humoral Immunity to Influenza Virus, G4366264114, G4411563302, G4865007500, G4875324880, Tryptophan derivatives in EHEC pathogenesis, G5310470050, SdiA regulation of EHEC virulence, G8512523905, Sugar regulation of EHEC virulance, Quorum Sensing Regulation of EHEC Virulence Genes, Molecular Microbiology Training Grant, Tryptophan derivatives in EHEC pathogenesis
OpenAlex ID: W3123505232