Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes
Year: 2019
Type: preprint
Abstract: We demonstrate the utility of biocatalytic hydroxylation with PtmO6 in the chemoenzymatic total synthesis of three oxidized kaurane natural products.
Source: ChemRxiv
Institution: Scripps Research Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3124161239