Year: 2021
Type: article
Abstract: Coronavirus disease 2019 (COVID-19) is a viral respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that varies from asymptomatic to severe illness and death. Old age, hypertension, obesity, diabetes, cardiovascular disease, chronic lung disease, and cancer predict a severe course, risk of hospitalization, and death. The US Food and Drug Administration recently approved remdesivir for the treatment of COVID-19 patients requiring hospitalization. 3 However, high mortality persists despite use of remdesivir. Remdesivir inhibits SARS-CoV-2 RNA polymerase, hindering viral replication. In patients with COVID-19, peak SARS-CoV-2 concentrations occur on Day 5 and most active replication in the throat during the first 5 days of symptoms onset. In rhesus macaques infected with SARS-
Source: Journal of Medical Virology
DOI: 10.1002/jmv.26792
Authors: Luigi X. Cubeddu, Robert J. Cubeddu
Institutions: Nova Southeastern University, Cleveland Clinic Florida
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3124454592