Year: 2021
Type: editorial
Abstract: Spatiotemporal molecular medicine is a new discipline of medicine to precisely understand the pathogenesis, history, and epidemiology, and aims to achieve prevention, diagnosis, and therapy at molecular levels for human diseases in multidimensional aspects related to a spatial and temporal context.The human body is a three-dimensional object with the space of length, width, and height, while the spatiotemporal concept demonstrates a fourdimensional continuum with the concept of time.Clinical spatialization of a disease should be considered at the levels of genetics (e.g., family tree, pedigree, germline heterogeneity), populations (e.g., regional distribution, epidemiological map), and individuals (e.g., inter-and intraorgan location and variation).Clinical temporalization covers the historical process and progression of disease occurrence and development, duration-based alteration of clinical phenomes, and dynamics of patient responses to therapy.Clinical trans-omics was proposed as a new approach to understand the disease from the cross-points among different layers of networks generated from the integration of clinical phenomics with molecular multi-omics.1 Clinical trans-omics provide three-dimensional information on clinical phenome(s) corresponding to molecular elements or the reverse, the understanding of moleculebased dimension in correlation with phenomes, and the potential of disease phenome-specific diagnostic biomarkers and therapeutic targets.In comparison, spatiotemporal molecular medicine presents a four-dimensional and dynamical picture of the disease by integrating clinical spatialization, temporalization, phenome, and molecular multi-omics for disease diagnosis, therapy, and prognosis.We propose that spatiotemporal molecular medicine will be an independent and merging discipline to meet the rapid development of medicine.The present editorial especially highlights spatiotemporal molecular medicine as a new vision and platform to understand the importance of spatial and temporal transcriptomics/proteomics, positioning of cell-cell interaction and communication,
DOI: 10.1002/ctm2.294
Authors: Xiangdong Wang, Jia Fan
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W3124765945