Year: 2011
Type: article
Abstract: Alzheimer's disease (AD) is initiated by the formation of extracellular amyloid-B (AB) neurotoxin. Our laboratory uses neurotrophic factor (NTF) mimetics to increase neuronal survival in the presence of AB. This project investigated the potential role of cathepsin-D in AB-induced cell death, and found through fluorescence substrate assay that cathepsin-D activity increases in AB-treated human neuronal cells. We also found that NTF treatment can increase the cellular levels of therapeutic anti-oxidative superoxide dismutase in the brains of AD mice.
Source: Digital WPI
Authors: Gregory Marshall Lobdell, Melanie Donahue
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3124934985