Work

The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins

Year: 2021

Type: article

Abstract: , and other genes upon SMCHD1 loss depend on TET proteins. These data identify SMCHD1 as an antagonist of the 2c-like state of ES cells and of TET-mediated DNA demethylation.

Source: Science Advances

DOI: 10.1126/sciadv.abb9149

Authors: Zhijun Huang, Jiyoung Yu, Wei Cui, Benjamin K. Johnson, Kyunggon Kim, Gerd P. Pfeifer

Institutions: Van Andel Institute, Asan Medical Center, University of Ulsan

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

OpenAlex ID: W3125462522

FWCI: 2.98

Cites: 67

Cited by: 52

Related to: 10