Year: 2021
Type: review
Abstract: Alzheimer's disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer's dementia.
Source: Frontiers in Physiology
Institutions: Southeast University, Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, Centre National de la Recherche Scientifique, Résistance Induite et Bioprotection des Plantes, Université de Reims Champagne-Ardenne, King Abdulaziz University, Princess Nourah bint Abdulrahman University, Albany College of Pharmacy and Health Sciences, Suez Canal University, King Saud University, Riphah International University, Government College University, Faisalabad, University of Dhaka
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3126053443