Work

Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide

Year: 2021

Type: article

Abstract: This study demonstrates, for the first time, that renal tubular excretion of trimethylamine N-oxide (TMAO) is inhibited by concomitant loop diuretic administration. The observed marked accumulation in the renal parenchyma, and to lesser extent, plasma, implies differential distributions of TMAO across various tissues and/or systems as a consequence of efflux channel control. A better understanding of TMAO renal clearance and its potential interactions with current and future therapies in patients with heart failure are warranted.

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2020.11.010

Authors: Daniel Y. Li, Zeneng Wang, Xun Jia, Di Yan, Diana M. Shih, Stanley L. Hazen, Aldons J. Lusis, W.H. Wilson Tang

Institutions: Cleveland Clinic, Stanford Medicine, Cleveland Clinic Research, Stanford University, NYU Langone Health, New York University, University of California, Los Angeles

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400

Funders: Fondation Leducq, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Gut microbiota and metabolite interactions in atherosclerosis, Gut Microbiota and Cardiometabolic Diseases, Gut Flora metabolism of dietary carnitine and cardiovascular disease

OpenAlex ID: W3126363066

FWCI: 2.053

Cites: 44

Cited by: 21

Related to: 10