Year: 2021
Type: review
Abstract: Numerous studies have sought to decipher the genetic and other mechanisms contributing to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand the etiology of the disease or to develop satisfactory treatments. Since the majority of diabetes susceptibility loci are mapped to non-coding regions within the genome, understanding the functions of non-coding RNAs in β-cell biology might provide crucial insights into the pathogenesis of type 1 (T1D) and type 2 (T2D) diabetes. During the past decade, numerous studies have indicated that long non-coding RNAs play important roles in the maintenance of β-cell mass and function. Indeed, lncRNAs have been shown to be involved in controlling β-cell proliferation during development and/or β-cell compensation in response to hyperglycaemia. LncRNAs such as TUG-1 and MEG3 play a role in both β-cell apoptosis and function, while others sensitize β-cells to apoptosis in response to stress signals. In addition, several long non-coding RNAs have been shown to regulate the expression of β-cell-enriched transcription factors in cis or in trans. In this review, we provide an overview of the roles of lncRNAs in maintaining β-function and mass, and discuss their relevance in the development of diabetes.
Source: Frontiers in Endocrinology
Authors: Livia López–Noriega, Guy A. Rutter
Institutions: Imperial College London, Nanyang Technological University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G130968091, G1335979935, Genetic and nutritional control of pancreatic beta cell identity., G1937207371, Roles of GWA genes in controlling pancreatic beta cell function and mass., G2040450235, Control of glucagon secretion by AMPK and related kinases., G434337789, Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881, G4426574518, G4781795914, G5482254092, G5673545276, The impact of long non-coding RNA at the Pax6 locus on beta cell identity and function, G6133425169, Defining the molecular and physiological mechanisms of pancreatic islet dysfunction which lead to type 2 diabetes, Coordination and Advancement of sub-Saharan Africa-EU Science & Technology Cooperation Network, Understanding pancreatic beta cell connectivity, Molecular mechanisms linking Sorcin to pancreatic beta cell lipotoxicity and ER Ca2+ stores., G7328074751, G7571465722, Roles of the type 2 diabetes (T2D)-associated gene C2cd4a in regulating glucose homeostasis in the mouse, G9000168923
OpenAlex ID: W3126403405