Mechanisms of severe acute intermittent hypoxia-induced phrenic long-term facilitation
Year: 2021
Type: article
Abstract: Distinct mechanisms give rise to pLTF induced by moderate and severe AIH. We demonstrate that, unlike moderate AIH, severe AIH-induced pLTF requires EPAC and PI3K/Akt and is marginally constrained by NADPH oxidase activity. Surprisingly, sAIH-induced pLTF requires MEK/ERK activity similar to moderate AIH-induced pLTF and is reduced by PKA inhibition. We suggest sAIH-induced pLTF arises from complex interactions between dominant mechanisms characteristic of moderate versus severe AIH-induced pLTF.
Source: Journal of Neurophysiology
Authors: Nicole L. Nichols, Gordon S. Mitchell
Institution: University of Wisconsin–Madison
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: G1206640087, Mechanisms of respiratory long-term facilitation, G2160637830, Enhanced respiratory plasticity in models of respiratory motor neuron death, G5429844357, Regulation of Intermittent Hypoxia-Induced Respiratory Motor Plasticity, Enhanced respiratory plasticity in models of respiratory motor neuron death, G7328599282
OpenAlex ID: W3126736340