Twenty years of pediatric diabetes surveillance: what do we know and why it matters
Year: 2021
Type: review
Abstract: SEARCH for Diabetes in Youth (SEARCH) was initiated in 2000 as a multicenter study to address major gaps in the understanding of childhood diabetes in the United States. An active registry of youth diagnosed with diabetes at age <20 years since 2002 assessed prevalence, annual incidence, and trends by age, race/ethnicity, sex, and diabetes type. An observational cohort nested within the population-based registry was established to assess the natural history and risk factors for acute and chronic diabetes-related complications, as well as the quality of care and quality of life of children and adolescents with diabetes from diagnosis into young adulthood. SEARCH findings have contributed to a better understanding of the complex and heterogeneous nature of youth-onset diabetes. Continued surveillance of the burden and risk of type 1 and type 2 diabetes is important to track and monitor incidence and prevalence within the population. SEARCH reported evidence of early diabetes complications highlighting that continuing the long-term follow-up of youth with diabetes is necessary to further our understanding of its natural history and to develop the most appropriate approaches to primary, secondary, and tertiary prevention of diabetes and its complications. This review summarizes two decades of research and suggests avenues for further work.
DOI: 10.1111/nyas.14573
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, University of Cincinnati, National Institutes of Health, Centers for Disease Control and Prevention, South Carolina Clinical and Translational Research Institute, Medical University of South Carolina, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Chronic Disease Prevention and Health Promotion, National Center for Advancing Translational Sciences
Awards: G1061576540, G1092462818, G1095442109, G1535104519, G1650250266, UCHSC Diabetes and Endocrinology Research Center, Colorado Clinical and Translational Science Institute (UL1), G2091809135, G22646245, G2320993242, G2698360221, G3013847213, G3437629819, Institute of Translational Health Sciences, South Carolina Clinical & Translational Research Institute (SCTR), Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study, G486112768, G4976965329, G5212289133, Center for Clinical and Translational Science and Training, G5304326513, G572024221, G5724597403, Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort Study, G7270065953, South Carolina Clinical & Translational Research Institute (SCTR), G832786732, Cincinnati Center for Clinical and Translational Sciences and Training, G874743574
OpenAlex ID: W3126761883