Overhauser dynamic nuclear polarization (ODNP)-enhanced two-dimensional proton NMR spectroscopy at low magnetic fields
Year: 2021
Type: article
Abstract: The majority of low-field Overhauser dynamic nuclear polarization (ODNP) experiments reported so far have been 1D NMR experiments to study molecular dynamics and in particular hydration dynamics. In this work, we demonstrate the application of ODNP-enhanced 2D J-resolved (JRES) spectroscopy to improve spectral resolution beyond the limit imposed by the line broadening introduced by the paramagnetic polarizing agent. Using this approach, we are able to separate the overlapping multiplets of ethyl crotonate into a second dimension and clearly identify each chemical site individually. Crucial to these experiments is interleaved spectral referencing, a method introduced to compensate for temperature-induced field drifts over the course of the NMR acquisition. This method does not require additional hardware such as a field-frequency lock, which is especially challenging when designing compact systems.
Source: Magnetic Resonance
Authors: Timothy J. Keller, Thorsten Maly
Institution: Bridge12 Technologies (United States)
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $992
Awards: G2172076701, An ODNP Probe to Study Hydration Dynamics in Membrane Protein, A Resonator for Pulsed ODNP Spectroscopy to Study Surface Hydration Dynamics, Compact, Integrated EPR Spectrometer for Dynamic Nuclear Polarization, G4871807375, Compact, Integrated EPR Spectrometer for Dynamic Nuclear Polarization, A Compact Hybrid Magnet with High Homogeneity for X-Band DNP/NMR and EPR Spectroscopy, An ODNP Probe to Study Hydration Dynamics in Membrane Protein, A Resonator for Pulsed ODNP Spectroscopy to Study Surface Hydration Dynamics
OpenAlex ID: W3126861363