Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder
Year: 2021
Type: article
Study design: Observational Study
Abstract: We investigated interactive roles of three metabolic glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1) and autism spectrum disorder (ASD) status in relation to blood Hg concentrations (BHC) of Jamaican children. We used data from 266 children (2-8 years) with ASD and their 1:1 age- and sex-matched typically developing (TD) controls. After adjusting General Linear Models for child’s age, socioeconomic status, consumption of leafy vegetables, fried plantain, canned fish, and the interaction between GSTP1 and GSTT1, we found significant interactions between GSTP1 and ASD status in relation to BHC either in a co-dominant or dominant genetic model for GSTP1(P < 0.001, P = 0.007, respectively). In the co-dominant model for the Ile105Val GSTP1 polymorphism, geometric mean (GM) BHC in ASD cases with genotype Ile/Ile were significantly higher than in cases with the Ile/Val genotype (0.73 vs. 0.48 µg/L, P = 0.01). In contrast, in TD controls with the Ile/Val genotype GM BHC were significantly higher than in those with the Ile/Ile genotype (0.72 vs. 0.49 µg/L, P = 0.03) or the Val/Val genotype (0.72 vs. 0.51 µg/L, P = 0.04). Although our findings are consistent with the role of GSTP1 in detoxification of Hg, replication in other populations is warranted.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,484
Funders: Michigan Department of Health and Human Services, University of Texas Health Science Center at Houston, Georgia Clinical and Translational Science Alliance, National Institutes of Health, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Fogarty International Center, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Center for Clinical and Translational Sciences (CCTS), G122915289, Center for Clinical and Translational Sciences (CCTS), G1676205432, G1826404230, G2015581692, G4978893582, Center for Clinical and Translational Sciences, G5644123735, G6036981074, Epidemiological Research on Autism in Jamaica - Phase II, Epidemiological Research on Autism in Jamaica, G8692209788, Gulf Coast Center for Precision Environmental Health
OpenAlex ID: W3126975345