Work

Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses

Year: 2021

Type: article

Abstract: Syntheses of complex molecular mixtures on the preparative scale are often challenging steps for chemists, which go hand in hand with expensive purification steps. Herein, the preparation and isolation of unsymmetrically substituted porphyrins, obtained from statistical reactions between two benzaldehydes, were investigated. Therefore, a semi‐automated modular process was developed to lower the consumable costs, save time, and reduce waste production. We utilized a monomode microwave reactor equipped with an autosampler, and a medium pressure liquid chromatography (MPLC) flash purification device, equipped with a UV/Vis detector and a re‐usable glass column packed with SiO2. With this method, it was possible to synthesize and purify several statistical porphyrin mixtures, while simultaneously reducing the environmental factor (E‐factor) significantly, compared to conventionally performed porphyrin syntheses. Our approach shows that a sustainable investigation of academically relevant low‐symmetrical porphyrins can be carried out feasibly, without sacrificing invested time.

Source: Chemistry - Methods

DOI: 10.1002/cmtd.202000055

Authors: Helen Hölzel, Maximilian Muth, Dominik Lungerich, Norbert Jux

Institutions: Friedrich-Alexander-Universität Erlangen-Nürnberg, Yonsei University, Institute for Basic Science

Language: English

Topic: Porphyrin and Phthalocyanine Chemistry

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: