Work

Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

Year: 2021

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2021.113252

Authors: Sameer Nikhar, Ioannis Siokas, Lisa Schlicher, Seungheon Lee, Mads Gyrd-Hansen, Alexei Degterev, Gregory D. Cuny

Institutions: University of Houston, Tufts University, University of Oxford, Ludwig Cancer Research

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke

Awards: Identification of atypical ubiquitylation and its role in inflammatory signalling., G1256809519, Targeting RIPK1 and RIPK2 kinases in mouse Experimental Autoimmune Encephalomyelitis, Dissection of the new pro-inflammatory components of the necrosome complex, Targeting RIPK3 in Age-Related Inflammation and Injury, G997507850

OpenAlex ID: W3127053806

FWCI: 1.7

Cites: 36

Cited by: 27

Related to: 10