Work

IFN-α facilitates the effect of sorafenib via shifting the M2-like polarization of TAM in hepatocellular carcinoma.

Year: 2021

Type: article

Abstract: T cells in HCCs. In conclusion, a combination of IFN-α and sorafenib have synergistic inhibitory effects on HCC growth and metastasis resulting from a shift in TAM polarization rather than their depletion. Our study supports the future clinical use of a combination of IFN-α and sorafenib for the treatment of advanced HCC.

Source: Europe PMC (PubMed Central)

Authors: Ze Zhang, Ying Zhu, Da Xu, Tian-En Li, Jian-Hua Li, Zi-Tian Xiao, Mo Chen, Xin Yang, Hu-Liang Jia, Qiong-Zhu Dong, Lun-Xiu Qin

Institutions: Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3127119060

FWCI: 1.006

Cites: 41

Cited by: 13

Related to: 10