Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study
Year: 2021
Type: article
Abstract: SCOPE: The lipidomic analysis of high-density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. METHODS AND RESULTS: A randomized, controlled, double-blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated-fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity. CONCLUSION: VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function.
Institutions: Technological Center of Nutrition and Health, EURECAT Centre Tecnològic de Catalunya, Universitat Rovira i Virgili, Instituto de Salud Carlos III, Hospital de Sant Pau, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Institut d'Investigacions Biomèdiques de Barcelona, Institut de Recerca Sant Pau, Universitat de Lleida, Agrotecnio - Centre for Food and Agriculture Research, Universitat Pompeu Fabra, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Centro de Investigación Biomédica en Red, Hospital Del Mar, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Consejo Superior de Investigaciones Científicas, Universidad de La Rioja, Instituto de Ciencias de la Vid y del Vino, Gobierno de La Rioja, Leiden University Medical Center, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institutes of Health Clinical Center, Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari Sant Joan de Reus
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W3127577850