Work

Amitriptyline Dependence and Its Associations: A Case Report and Literature Review

Year: 2021

Type: article

Abstract: Amitriptyline, the second antidepressant invented next to imipramine, is indicated in many psychiatric conditions as well as for some organic disorders. The drug acts by increasing the availability of monoamines in the central nervous system postsynaptic clefts. Amitriptyline has long been suspected for abusive potential based on a few case reports, and the reports add evidence in favor of the hypothesis. This case report brings such material to the arena of evidence and discusses the probable mechanisms by which patients turn to abusing and be addicted to the drug. The article also argues matters associated with drug dispensing that might raise the risk of misuse of the drug, especially in countries where strict legislation for accessibility of prescribed drugs is not in practice.

Source: Case Reports in Psychiatry

DOI: 10.1155/2021/6647952

Authors: T. Umaharan, S. Sivayokan, S. Sivansuthan

Institution: Jaffna Teaching Hospital

Language: English

Topic: Opioid Use Disorder Treatment

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790