Year: 2020
Type: article
Abstract: The utilization of UV filter molecules in sunscreens is crucial in mitigating the harmful effects of UV radiation; specifically, reducing the likelihood of developing erythema, photoaging, and carcinogenesis.However, the Food and Drug Administration (FDA) approved UV filter molecule, avobenzone (AV), rapidly degrades when exposed to UV light.This degradation results from a photochemical reaction from its enol isomer to its diketone isomer, which decreases its absorption of UVA light.The objective of this project is to determine how various amphipathic molecules, also called surfactants, can be used to protect avobenzone from degrading, and in turn maintain a high photo-absorption capacity over time.Multiple surfactants were tested, both above and below their critical micelle concentrations.The critical micelle concentration is the concentration at which the surfactant molecules organize into self-contained capsules in water.We examined the surfactant molecules sodium dodecylbenzenesulfonate (SDBS), sodium dodecyl sulfate (SDS), cetrimonium bromide (CTAB), tetradecyltrimethylammonium bromide (TTAB), and sodium laurate (SL).These were selected to vary chain length, charge, and polar head size to determine which properties promote the highest photostability.Following the avobenzone and surfactant investigation, surfactants will be used in formulations to test their effectiveness on improving photoprotection of the skin.Specifically, two-photon fluorescence imaging of the skin will be used to detect how our formulations affect free radical damage in the skin.The goal is to utilize stabilized avobenzone to implement into consumer products which reduce carcinogenesis rates amongst others. III.Results and Discussion IV.Conclusion V.
Author: Miles Cutuli
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3127901541