Work

Myeloid malignancies with 5q and 7q deletions are associated with extreme genomic complexity, biallelic TP53 variants, and very poor prognosis

Year: 2021

Type: article

Abstract: Acute myeloid leukemia (AML) is an aggressive myeloid neoplasm representing the most common type of acute leukemia in adults 1 , 2 . AML is classified into multiple genetic subtypes based on recurrent structural variations (SVs), copy number variations (CNVs), aneuploidies, and single nucleotide variants (SNVs). These genetic subtypes inform prognosis and influence clinical management 3 , 4 , 5 , 6 .

Source: Blood Cancer Journal

DOI: 10.1038/s41408-021-00416-4

Authors: Beth A. Pitel, Neeraj Sharma, Cinthya Zepeda-Mendoza, James B. Smadbeck, Kathryn E. Pearce, Joselle M. Cook, George Vasmatzis, Zohar Sachs, Rashmi Kanagal-Shamanna, David Viswanatha, Sheng Xiao, Robert B. Jenkins, Xinjie Xu, Nicole L. Hoppman, Rhett P. Ketterling, Jess F. Peterson, Patricia T. Greipp, Linda B. Baughn

Institutions: Mayo Clinic, ARUP Laboratories (United States), University of Minnesota, Masonic Cancer Center, The University of Texas MD Anderson Cancer Center, Brigham and Women's Hospital, Harvard University

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,480

Funders: Mayo Clinic, National Cancer Institute

Award: Mayo Clinic Comprehensive Cancer Center Support Grant

OpenAlex ID: W3128060698

FWCI: 1.384

Cites: 15

Cited by: 17

Related to: 10