Work

Chronic pain following spinal cord injury: Current approaches to cellular and molecular mechanisms.

Year: 2018

Type: article

Abstract: Traumatic spinal cord injury (SCI) has devastating implications for patients, including a high prevalence of chronic pain. Despite advancements in our understanding of the mechanisms involved post-SCI, there are no effective treatments for chronic pain following injury. The development of new treatment interventions for pain is needed, but this requires improved models to assess injury-related cellular, neurophysiological and molecular changes in the spinal cord. Here, we will discuss recent animal models for SCI, molecular screening for altered patterns of gene expression, and the importance of injury severity and timing after SCI.

Source: PubMed

Authors: Jessica R Yasko, Richard E Mains

Institution: UConn Health

Language: English

Topic: Spinal Cord Injury Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Cell Biology of Bioactive Peptide Secretion, Cell Biology of Bioactive Peptide Secretion