Work

Tumor-intrinsic and -extrinsic (immune) gene signatures robustly predict overall survival and treatment response in high grade serous ovarian cancer patients.

Year: 2021

Type: article

Abstract: ) in the high and low risk groups, respectively. The gene signature had two components: intrinsic (proliferation, metastasis, autophagy) and extrinsic (immune evasion). Moderate/high risk patients had more partial and non-responses to primary therapy than low risk patients (odds ratio = 4.54, P < 0.001). We concluded that the overall survival and response to primary therapy in ovarian cancer is best assessed using a combination of gene signatures. A combination of genes which combines both tumor intrinsic and extrinsic functions has the best prediction. Validation studies are warranted in the future.

Source: PubMed

Authors: David P Mysona, Lynn Tran, Shan Bai, Bruno Dos Santos, Sharad Ghamande, John Chan, Jin-Xiong She

Institutions: University of North Carolina at Chapel Hill, Augusta University, Palo Alto Medical Foundation

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3128783136

FWCI: 0.702

Cites: 98

Cited by: 4

Related to: 10