Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies
Year: 2021
Type: article
Abstract: Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long‐term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group‐based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person‐years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person‐years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00‐1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08‐2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87‐1.00) was also observed. HRs of 1.48 (95% CI: 1.10‐1.99) for noncardia and 0.51 (95% CI: 0.26‐1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
Source: International Journal of Cancer
DOI: 10.1002/ijc.33504
Authors: Harindra Jayasekara, Robert J. MacInnis, Leila Lujan‐Barroso, Ana‐Lucia Mayen‐Chacon, Amanda J. Cross, Bengt Wallner, Domenico Palli, Fulvio Ricceri, Valeria Pala, Salvatore Panico, Rosario Tumino, Tilman Kühn, Rudolf Kaaks, Kostas Tsilidis, Maria‐Jose Sánchez, Pilar Amiano, Eva Ardanaz, María Dolores Chirlaque López, Susana Merino, Joseph A. Rothwell, Marie‐Christine Boutron‐Ruault, Gianluca Severi, Hanna Sternby, Emily Sonestedt, Bas Bueno‐de‐Mesquita, Heiner Boeing, Ruth Travis, Torkjel M. Sandanger, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Anne Tjønneland, Yi Yang, Allison M. Hodge, Hazel Mitchell, Andrew Haydon, Robin Room, John L. Hopper, Elisabete Weiderpass, Marc J. Gunter, Elio Riboli, Graham G. Giles, Roger L. Milne, Antonio Agudo, Dallas R. English, Pietro Ferrari
Institutions: The University of Melbourne, Cancer Council Victoria, La Trobe University, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, World Health Organization, Centre international de recherche sur le cancer, Imperial College London, University Hospital of Umeå, Umeå University, University of Turin, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, German Cancer Research Center, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Biogipuzkoa Health Research Institute, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Gobierno del Principado de Asturias, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, University of Florence, Lund University, National Institute for Public Health and the Environment, University of Potsdam, University of Oxford, UiT The Arctic University of Norway, Hellenic Health Foundation, National and Kapodistrian University of Athens, University General Hospital Attikon, University of Copenhagen, Danish Cancer Society, UNSW Sydney, The Alfred Hospital, Alfred Health, Stockholm University, Monash Health, Monash University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,600
Funders: World Health Organization, University of Kentucky, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, Stroke Association, European Commission, VicHealth, Institut National de la Santé et de la Recherche Médicale, Cancerfonden, Ligue Contre le Cancer, Stavros Niarchos Foundation, Deutsche Krebshilfe, Foundation for Alcohol Research and Education, Medical Research Council, National Health and Medical Research Council, Cancer Council Victoria, Instituto de Salud Carlos III
Awards: G1549970566, G1788645866, G2037793313, G2130387517, G219746026, Health 2020, G2841678936, G2919394747, G3446711264, G3535040709, G3575964969, G3729156826, G4041385912, G4042319840, G4081633361, G422445311, G4409035895, G5315906942, G5706284561, G5757053897, G5897142711, G602992300, G6085534252, NIHR Senior Investigator Award, G6177794165, G6191607766, G6594529311, G6646763346, Epidemiology of Chronic Disease, Health Interventions and DNA Studies, G6816762977, G6820515600, G6957823285, G7042089715, G7180840450, G7199237069, Alcohol, diet and body fatness as risk factors for stomach cancer and its subtypes: a pooled analysis of prospective studies from the NCI Cohort Consortium, Precision Public Health for major cancers - novel approaches to building the genetic, epigenetic and lifestyle knowledge base for assessing risk and prognosis, G734127494, G8123808567, G8797697851, G8963950986
OpenAlex ID: W3128855437