Year: 2021
Type: review
Abstract: Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. In this review we consider the supporting evidence in terms of glucose control and quality of life for presently available closed-loop systems and those in development, including dual-hormone closed-loop systems. We also comment on alternative 'do-it-yourself' closed-loop systems. We remark on issues associated with clinical adoption of these approaches, including training provision, and consider limitations of presently available closed-loop systems and areas for future enhancements to further improve outcomes and reduce the burden of diabetes management.
Source: Diabetologia
Authors: Charlotte K. Boughton, Roman Hovorka
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
Funders: Leona M. and Harry B. Helmsley Charitable Trust, Wellcome Trust, National Institute for Health and Care Research, Diabetes UK, European Commission, NIHR Cambridge Biomedical Research Centre, National Institute of Diabetes and Digestive and Kidney Diseases, NIHR Evaluation Trials and Studies Coordinating Centre
Awards: G2018687014, G2166940007, Institute of Metabolic Science., G434337789, Institute of Metabolic Science., 24/7 closed-loop in older subjects with type 1 diabetes, G5246447471, Home testing of 24/7 closed-loop control in children and adolescents with type 1, Effect of closed loop insulin delivery from onset of diabetes in youth on progression of type 1 diabetes, G8589133502, G8758826526, The artificial pancreas in children aged 1 to 7 years with type 1 diabetes
OpenAlex ID: W3128903399