Evaluation of plasma fibrinogen, D‐dimer and C‐reactive protein as predictive parameters for coronary heart diseases in type 2 diabetic patients
Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: Disordered hemostatic mechanisms can play a role in the pathogenesis of macrovascular complications in type 2 diabetes either by leading to hypercoagulable state, or as circulating markers for arteriosclerosis. Aim: To evaluate the plasma levels of fibrinogen, D‐dimer and C‐reactive protein in patients with type 2 Diabetes mellitus (DM) and find a relation with disease duration, diabetic control and ischaemic heart disease (IHD). Patients and methods: Sixty adults attending the National Diabetes Center at Al‐Mustansiriya University were randomly selected and divided into 3 groups, 20 patients each. Group 1 and 2 consisted of type 2 diabetic patients without and with history of ischemic heart disease, respectively. Group 3 included 20 healthy controls. Blood was collected for measurement of fibrinogen, D‐dimer, C‐reactive protein and HbA1C. Results: Mean plasma D‐dimer and CRP but not fibrinogen were significantly higher in group 1 and 2 compared to the control group, in which they were significantly higher in group 2 than group 1. CRP and fibrinogen but not D‐dimer levels were positively correlated with HbA1C levels in the diabetic groups. The levels of plasma fibrinogen, Ddimer and CRP were significantly increased in diabetic patients with increase in the disease duration. Only levels of CRP had a significant relation with the history and type of ischemic heart disease. Conclusions: Hyperglycemia, insulin resistance and chronic inflammatory stress may be the causative factors for abnormal levels of hematological markers in type 2 DM. Their effect is augmented by the duration of DM and the association with IHD.
Source: Mustansiriya Medical Journal
Authors: Nuha A. Muhsin, Subh S. Al-Mudallal
Institution: Nahrain University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3129310163