Work

SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles

Year: 2021

Type: article

Abstract: T lymphocytes were negligible. In myeloid target cells, however, virion incorporation of S5 potently suppressed infectivity and promoted innate immune recognition of HIV-1 particles characterized by proinflammatory cytokine production. Both effects were not observed in cells of all donors analyzed, were exerted independently of one another, and were counteracted by the HIV-1 pathogenesis factor Nef. These results identify the sensitization of HIV-1 particles for innate immune recognition by myeloid target cells as a novel activity of S5 and emphasize the need to study RF function in the context of primary target cells and taking donor variabilities into account.

Source: Journal of Virology

DOI: 10.1128/jvi.02372-20

Authors: Virginia Pierini, Lara Gallucci, Christina M. Stürzel, Frank Kirchhoff, Oliver T. Fackler

Institutions: University Hospital Heidelberg, University Hospital Ulm, German Center for Infection Research

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deutsches Zentrum für Infektionsforschung, Deutsche Forschungsgemeinschaft