coreNASH: Multi-stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment
Year: 2021
Type: article
Abstract: The increasing prevalence and burden of nonalcoholic steatohepatitis (NASH) has spurred the development of new treatments and a need to consider outcomes used for NASH treatment decision making. Development of a NASH core outcome set (COS) can help prioritize outcomes of highest importance by incorporating the perspectives from a variety of decision makers. coreNASH was an initiative to develop a COS for NASH using a modified Delphi consensus process with a multi-stakeholder voting panel. A candidate outcome list was created based on a literature review and key informant interviews. The candidate outcome list was then condensed and prioritized through three rounds of online voting and through discussion at an in-person meeting. Outcomes were retained or eliminated based on predetermined consensus criteria, which included special weighting of patients’ opinions in the first two voting rounds. The coreNASH Delphi panel included 53 participants (7 patients, 10 clinicians and researchers, 7 health technology assessors, 22 industry representatives, 2 regulators, and 5 payers) who considered outcomes for two NASH-related COS: one for NASH without cirrhosis (F2-F3) and one for NASH with cirrhosis (F4). The initial candidate outcome list for both disease stages included 86 outcomes. The panel agreed on including two core outcomes for NASH without cirrhosis and nine core outcomes for NASH with cirrhosis in the COS. Conclusion: A consensus-based COS has been developed that can be used across the life cycle of NASH treatments. Outcomes included can contribute to decision making for regulatory, market access, and on-market decision making. Including the coreNASH COS in clinical development programs will facilitate improved comparisons and help decision makers assess the value of new products.
Source: Hepatology Communications
DOI: 10.1002/hep4.1678
Authors: Elizabeth Clearfield, Veronica Miller, Joseph Nadglowski, Katherine Barradas, Jennifer Al Naber, Arun J. Sanyal, Brent A. Neuschwander-Tetri, Donna A. Messner, William Baldyga, Maria-Magdalena Balp, Catherine Brun-Strang, Robyn Carson, Wayne Eskridge, Kurinchi Gurusamy, Lars Hansen, Morten Hansen, Katy Harrison, Andras Harsanyi, Anders Hvelplund, Zoltán Kaló, Marko Korenjak, EJ Milne, Euan McLeod, Michelle Mocarski, Joachim Musaeus, Fady Ntanios, Mazen Noureddin, Daniel Ollendorf, Jan Oscarsson, Stephen Rossi, Vlad Ratziu, Yaron Rotman, Leonardo Ruiz-Casas, Lewis Sandy, Jörn M Schattenberg, Mohammad Shadab Siddiqui, Gregory Steinberg, Ethan Weiss, Keith White, José Willemse, Kathy Wright, Michael Zemel
Language: English
Topic: Delphi Technique in Research
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W3129676201