Work

The role of immune-mediated alterations and disorders in ALS disease

Year: 2021

Type: review

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to neuronal death in the brain and spinal cord. Over the last decades, evidence has emerged regarding the functional diversity of astrocytes, microglia, and T cells in the central nervous system (CNS), and the role of neuroinflammation in ALS. In this review, we summarize current knowledge regarding neuroinflammation in ALS, both at the level of specific molecular pathways and potential cellular pathways as well as outline questions about the immune mechanisms involved in ALS pathogenesis.

Source: Human Immunology

DOI: 10.1016/j.humimm.2021.01.017

Authors: João Rodrigues Lima-Junior, David Sulzer, Cecilia S. Lindestam Arlehamn, Alessandro Sette

Institutions: La Jolla Institute for Immunology, New York State Psychiatric Institute, Columbia University, University of California San Diego

Language: German

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,110