Work

Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease

Year: 2021

Type: article

Abstract: Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow's disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow's disease, highlighting the differences in diagnosis, risk stratification and patient management, but also the still significant gaps in understanding the exact pathophysiology of these two phenotypes.

Source: Journal of Cardiovascular Development and Disease

DOI: 10.3390/jcdd8020023

Authors: Aniek L. van Wijngaarden, Boudewijn P. T. Kruithof, Tommaso Vinella, Daniela Q. C. M. Barge-Schaapveld, Nina Ajmone Marsan

Institutions: Leiden University Medical Center, University of Southampton

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,728