LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions
Year: 2021
Type: article
Abstract: Background To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals. Results The regulatory landscape around genes included both tissue-shared and tissue-specific regulatory regions, where tissue-specific promoters and enhancers evolved most rapidly. Genomic regions switching between promoters and enhancers were more common across species, and less common across tissues within a single species. Long Interspersed Nuclear Elements (LINEs) played recurrent evolutionary roles: LINE L1s were associated with tissue-specific regulatory regions, whereas more ancient LINE L2s were associated with tissue-shared regulatory regions and with those switching between promoter and enhancer signatures across species. Conclusions Our analyses of the tissue-specificity and evolutionary stability among promoters and enhancers reveal how specific LINE families have helped shape the dynamic mammalian regulome.
Source: Genome biology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,890
Funders: Wellcome Trust, Francis Crick Institute, European Molecular Biology Laboratory, Cancer Research UK, Defence Science and Technology Laboratory, Medical Research Council, European Research Council, Cancer Research UK Cambridge Institute, University of Cambridge, H2020 European Research Council, FP7 Ideas: European Research Council
Awards: Regulatory potential of repeat elements in the evolution of tissue-specific transcription, Evolutionary genetics of transcription factor binding in closely related mammals, CTCF control of genome stability in ageing, G3919102218, G4529206470, G4761255497, G5200348298, G776593930, G8455414079
OpenAlex ID: W3130610799