Work

CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants

Year: 2021

Type: article

Study design: Observational Study

Abstract: This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofab143

Authors: Andrew D Redd, Alessandra Nardin, Hassen Kared, Evan M Bloch, Andrew Pekosz, Oliver Laeyendecker, Brian Abel, Michael Fehlings, Thomas C Quinn, Aaron A R Tobian

Institutions: National Institutes of Health, Johns Hopkins University, National Institute of Allergy and Infectious Diseases

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,465

Funders: Johns Hopkins University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, NHLBI Division of Intramural Research

Awards: The Malaria Transfusion Risk (MATRix) Study, Penile Microbiome, Inflammation and HIV Susceptibility During Sexual Debut and Maturation Among Male Adolescents, G3669211853, G4619494700, Unlocking the Potential of HIV-Infected Deceased Donors for Organ Transplantation

OpenAlex ID: W3184535585

FWCI: 7.288

Cites: 13

Cited by: 105

Related to: 10