Systematic review on the use of patient-reported outcome measures in brain tumor studies: part of the Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) initiative
Year: 2021
Type: review
Study design: Systematic Review
Abstract: BACKGROUND: The Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) working group aims to provide guidance on the use of PROs in brain tumor patients. PRO measures should be of high quality, both in terms of relevance and other measurement properties. This systematic review aimed to identify PRO measures that have been used in brain tumor studies to date. METHODS: A systematic literature search for articles published up to June 25, 2020 was conducted in several electronic databases. Pre-specified inclusion criteria were used to identify studies using PRO measures assessing symptoms, (instrumental) activities of daily living [(I)ADL] or health-related quality of life (HRQoL) in adult patients with glioma, meningioma, primary central nervous system lymphoma, or brain metastasis. RESULTS: A total of 215 different PRO measures were identified in 571 published and 194 unpublished studies. The identified PRO measures include brain tumor-specific, cancer-specific, and generic instruments, as well as instruments designed for other indications or multi- or single-item study-specific questionnaires. The most frequently used instruments were the EORTC QLQ-C30 and QLQ-BN20 (n = 286 and n = 247), and the FACT-Br (n = 167), however, the majority of the instruments were used only once or twice (150/215). CONCLUSION: Many different PRO measures assessing symptoms, (I)ADL or HRQoL have been used in brain tumor studies to date. Future research should clarify whether these instruments or their scales/items exhibit good content validity and other measurement properties for use in brain tumor patients.
Source: Neuro-Oncology Practice
DOI: 10.1093/nop/npab013
Authors: Linda Dirven, Maartje E Vos, Tobias Walbert, Terri S Armstrong, David Arons, Martin J van den Bent, Jaishri Blakeley, Paul D Brown, Helen Bulbeck, Susan M Chang, Corneel Coens, Mark R Gilbert, Robin Grant, Rakesh Jalali, Danielle Leach, Heather Leeper, Tito Mendoza, Lakshmi Nayak, Kathy Oliver, Jaap C Reijneveld, Emilie Le Rhun, Larry Rubinstein, Michael Weller, Patrick Y Wen, Martin J B Taphoorn
Institutions: Leiden University Medical Center, Medisch Centrum Haaglanden, Stichting Haaglanden Medisch Centrum, Henry Ford Health, Henry Ford Hospital, National Institutes of Health, National Cancer Institute, Center for Cancer Research, National Brain Tumor Society, Erasmus MC Cancer Institute, Johns Hopkins University, Johns Hopkins Medicine, Mayo Clinic, University of California, San Francisco, European Organisation for Research and Treatment of Cancer, Edinburgh Royal Infirmary, Tata Memorial Hospital, The University of Texas MD Anderson Cancer Center, Center for Neuro-Oncology, Dana-Farber Cancer Institute, Amsterdam University Medical Centers, Stichting Epilepsie Instellingen Nederland, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Zurich, University Hospital Zurich
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: G432951744
OpenAlex ID: W3130770249