Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
Year: 2021
Type: article
Abstract: Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy-related genes (ATGs) in non-degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.
Source: FASEB BioAdvances
Authors: Andrew M. Leidal, Jayanta Debnath
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,420
Awards: Stromal Fibroblast Autophagy In Tumor Progression and Desmoplasia, Autophagy as a microenvironmental regulator of tumorigenesis and resistance, Deciphering Autophagy-Dependent Secretion In Cancer Via Proximity-Based Biotinylation, Endolysosomal defects in secretory autophagy and microglial toxicity in FTD, Autophagy and Pro-metastatic Differentiation
OpenAlex ID: W3130988593