Work

CNS critical periods: implications for dystonia and other neurodevelopmental disorders

Year: 2021

Type: review

Abstract: Critical periods are discrete developmental stages when the nervous system is especially sensitive to stimuli that facilitate circuit maturation. The distinctive landscapes assumed by the developing CNS create analogous periods of susceptibility to pathogenic insults and responsiveness to therapy. Here, we review critical periods in nervous system development and disease, with an emphasis on the neurodevelopmental disorder DYT1 dystonia. We highlight clinical and laboratory observations supporting the existence of a critical period during which the DYT1 mutation is uniquely harmful, and the implications for future therapeutic development.

Source: JCI Insight

DOI: 10.1172/jci.insight.142483

Authors: Jay Li, Sumin Kim, Samuel S. Pappas, William T. Dauer

Institutions: University of Michigan, The University of Texas Southwestern Medical Center

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,100