Work

Transcriptomic profiling of developing melanocortin neurons reveals a role for Prdm12 in energy balance

Year: 2019

Type: article

Abstract: The anterior cingulate cortex (ACC) and insular cortex (IC) are two key cortical regions for the process of pain and its related emotions.In this talk, I will discuss increasing evidence from rodent studies that ACC/IC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect.In particular, one form of long-term potentiation (LTP), which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state.Another form of LTP, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.Finally, I will discuss the potential use of a selective AC1 inhibitor NB001 for future treatment of chronic pain and anxiety.

Source: IBRO Reports

DOI: 10.1016/j.ibror.2019.07.076

Author: Chen Liu

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500