Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Year: 2021
Type: review
Abstract: Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
Source: Advanced Drug Delivery Reviews
Authors: Zahari Vinarov, Bertil Abrahamsson, Per Artursson, Hannah Batchelor, Philippe Berben, Andreas Bernkop-Schnürch, James Butler, Jens Ceulemans, Nigel Davies, Didier Dupont, Gøril Eide Flaten, Nikoletta Fotaki, Brendan T. Griffin, Vincent Jannin, Janneke Keemink, Filippos Kesisoglou, Mirko Koziolek, Martin Kuentz, Alan Mackie, Antonio J. Meléndez-Martínez, Mark McAllister, Anette Müllertz, Caitriona M. O'Driscoll, Neil Parrott, Jadwiga Paszkowska, Petr Pavek, Christopher J.H. Porter, Christos Reppas, Cordula Stillhart, Kiyohiko Sugano, Elena Toader, Kateřina Valentová, Maria Vertzoni, Saskia N. De Wildt, Clive G. Wilson, Patrick Augustijns
Institutions: Sofia University "St. Kliment Ohridski", KU Leuven, AstraZeneca (Sweden), Uppsala University, University of Strathclyde, UCB Pharma (Belgium), Universität Innsbruck, GlaxoSmithKline (United Kingdom), Janssen (Belgium), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Science et Technologie du Lait et de l'Oeuf, UiT The Arctic University of Norway, University of Bath, University College Cork, Merck & Co., Inc., Rahway, NJ, USA (United States), AbbVie (Germany), University of Basel, FHNW University of Applied Sciences and Arts Northwestern Switzerland, University of Leeds, Universidad de Sevilla, Pfizer (United Kingdom), University of Copenhagen, Roche (Switzerland), Charles University, University of Hradec Králové, Monash University, National and Kapodistrian University of Athens, Ritsumeikan University, Grigore T. Popa University of Medicine and Pharmacy, Czech Academy of Sciences, Institute of Microbiology, Radboud University Nijmegen, Radboud University Medical Center
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
OpenAlex ID: W3131365424