Ischemia: Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration (Adv. Sci. 4/2021)
Year: 2021
Type: article
Abstract: In article number 2002500 by Katja Schenke-Layland and co-workers, the basement membrane protein Nidogen-1 is shown to promote tissue survival and regeneration in ischemic conditions. Once thought as a simple linker protein, Nidogen-1 increases heart function and decreases scaring in a myocardial infarction model, rescues pancreatic beta-cell function in hypoxia, and modulates the immune system, demonstrating the multifaceted effect of Nidogen-1.
Source: Advanced Science
Authors: Aline Zbinden, Shannon L. Layland, Max Urbanczyk, Daniel A. Carvajal Berrio, Julia Marzi, Monika Zauner, Anne Hammerschmidt, Eva M. Brauchle, Katrin Sudrow, Simon Fink, Markus Templin, Simone Liebscher, Gerd Klein, Arjun Deb, Garry P. Duffy, Gay M. Crooks, Johannes A. Eble, Hanna K. A. Mikkola, Ali Nsair, Martina Seifert, Katja Schenke‐Layland
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,000
OpenAlex ID: W3131395851